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Bone Safety

发布时间 2018-03-04
点击次数 23
  • 基本参数
  • 部件材质
  • 应用概述
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         Bone Safety


         Bone Structure


         A.Align to biomechanical loading

         Anatomical structure of bones depends mainly on the genetic and biomechanical influences to their length, width, shape and contour, and strength. In general, mechanical rules, structure aligBone Safetynment streams along the loading axis.

         B.Cortex and trabecular

         Bone has cortical shell as the predominant weight bearing component and trabeculae as the sponge cushion within the marrow.

         C.Blood Supply

         Bone marrow is the source for hematopoiesis, therefore has conspicuous blood supply networks.


         Bone Resorption Vs Bone Formation


         Maintenance on bone integrity is crucial to hematopoiesis, locomotion, and muscles/tendons insertion; and is pivotal to calcium homeostasis, hormonal metabolism and weight bearing daily activities. The gain on bone mass is through modeling where bone formation is greater than that of bone resorption. The bone loss during aging is through greater bone resoption to that of bone formation in remodeling.


         Drug Effects


         Maintenance of bone mass is through the balance between amount of bone resorbed and formed by cumulative sum from the outputs of BMUs. Drugs that distributed through blood flow caBone Safetyn easily affect the balance of bone resorption and formation. The known chemicals, such as fluoride, aluminum, lead, etc. and inflammation/immune modulator medicine, such as cyclosporine, steroids, conjugated antibody, etc. can have detrimental effects on bone physiology and lead to bone pathology with increased risk of fracture as the end results. It is, therefore, prudent to examine the influence of medicinal products either small molecules or protein-based agents on bone for safety purpose.


         Bone Safety Studies



         We Are Able to Perform Bone Safety Studies in the Following Situations

         *Compound that is known to modify the bone remodeling process

         *Compound that is known to modify the bone remodeling process

         *Compound that may have an effect on calcium homeostasis, PTH/CT/1,25VitD axis Compound that alters the differentiation of marrow cells

         *Compound that is composed of heavy metals Compound that may affect gonadal hormone status

         *Compound that will be given to pediatric or renal patients

         *Compound that may have an effect at the pituitary/hypothalamus axis


         Tools Used by the Bone Biologist

         *Bone markers (Turnover, Formation and Resorption Markers)

         *Bone Mass/ Mineral Density Determinations (X-ray, DXA, pQCT, CT scan  and Micro-CT) Bone Strength Determinations (Biome*chanical Testing)

          *Bone Histomorphometry

          *Histopathology





                        Bone SafetyBone SafetyBone Safety

                      Bone Histomorphometry           Histology - Abnormal Fibrosis            Intra-condyle Implantation

                                                                          Tissue in Rat Chronic Renal Failure


Histomorphometry Parameters


Static parameters:  bone area/perimeter and               Unusual tissues:     fibrosis, woven bone,excessive osteoid, diffused                                                                                                                   bone formation, defect and repair area, implant/bone surface

Dynamic parameters: bone formation rate            Exotic parameters:  wall width, activation frequency, mineralization lag time


Cellular parameters:  osteoblasts, osteoclasts,



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