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Immuno-Oncology

发布时间 2018-03-05
点击次数 604
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Immuno-Oncology


 Introduction


Immuno-therapy has now been representing a significant paradigm shift in cancer treatment after the promising clinical data from the immune-checkpoint modulators. Profiling anti-cancer drug candidates with clinical relevant animal models provides fundamental information for oncology research and development. 

PharmaLegacy offers comprehensive oncology and immuno-oncology drug discovery platform which includes in vivo efficacy evaluation in various validated tumor models, target identification and validation, PK/PD and exploratory toxicology to support our global clients/ partners for their portfolio development.


 PharmaLegacy Immuno-Oncology Models


 Humanized mouse model: Human immune system + Human tumor:

                                                                                        Model development 

Immuno-Oncology                          Immuno-Oncology

                                 Effects of PD-1 or Bi-specific antibodies on tumor growth inhibition in humanized mice


Immuno-Oncology      Immuno-Oncology

     * NOG mice engraftment with hu-CD34+ stem cells

     * hCD45+ cells reach >40% after engraftment in peripheral blood

     * Human lymphocyte subsets (hCD3+ CD4+ CD8+ cells) increase in peripheral blood, lymphatic and tumor tissue

     * Model is validated with PD-1 and PD-L1 antibodies


 Syngeneic mouse models:

Immuno-Oncology












  Used to interrogating novel immune-oncology treatments via activating the mouse immune system

* Model types: subcutaneous, orthotopic and metastatic

* 22 models covering 14 cancer types and more on going

* Validated with anti-PD-1, PD-L1 and anti-CTLA-4 antibodies


CDX models:

                        >90 human tumor cell lines covering >20 cancer types CDX models

Immuno-Oncology       Immuno-Oncology

     Immuno-Oncology




PDX models:                                                                             Research Tools:

Immuno-Oncology                       Immuno-Oncology

  • Patient information with diagnosis and treatment history

  • 367 PDX models covering 6 cancer types and more ongoing




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