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Histology Services

发布时间 2018-03-05
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     Histology Services


Introduction


     PharmaLegacy (PL) provides contract histology, immunohistochemistry and pathology services to the biopharmaceutical and medical device industry. Whether preparing a single biopsy or a complete study, PL offers high-quality slide preparation, pathological evaluation and report preparation in a timely and cost-effective manner. Our team of highly trained and experienced board-certified veterinary pathologists, skilled and detail-oriented technical personnel and full-time quality assurance staff are committed to providing the highest level of quality. All PL studies are conducted within our laboratories, under the direct supervision of our pathologists, quality assurance unit and PhD-level scientific managers. For preparation of histology and pathology studies for regulatory submission, PL follows FDA, OECD, and CFDA guidelines.



     Regulatory Histopathology


     Our histopathology team provides expert contract histologic slide preparation and regulatory pathology evaluation of tissues from both supporting GLP and non-GLP toxicology studies, pharmacology and efficacy studies, basic research and diagnostics. Our clients include pharmaceutical, biotechnology and medical device companies, universities, grant funded organizations, and basic researchers.

Sections

Frozen Sections

     We have the modern cryostat and have the capabilities of sectioning almost any typeHistology Services

of specimen, including mouse bone sections. We can section and mount your specimens to custom orders.

     

     

     

     Paraffin Sections

     Most of our work is the routine processing and embedding to paraffin Histology Services

block and we offer many options in this service. To save your time, you

can trim the tissues and place them in your own labeled processing cassettes. 

You can even perform your own processing and paraffin infiltrating and 

embedding and ask us just to do the sectioning. For quality slides please 

use our services followed the proper trimming technique, correct processing

solutions and infiltrating and embedding paraffin and processing schedules.

     

Plastic sections

                                             Plastic sections are used for the evaluation of 

                                              non-decalcified bone, devices such as stents 

or bone pins and implanted material such as Histology ServicesHistology Services

suture. Hard biological tissue, such as bone 

and tissue containing metal can be embedded

in plastics, sectioned with a low-speed saw and

either ground to a thickness suitable for histological 

examination or sectioned with a tungsten knife.


Histochemical Stains

     The PL histology laboratory is skilled in the histologic preparation of a large variety of histopathology and special stains on frozen, paraffin and plastic embedded tissues from a range of both common and unusual research and discovery models. We can accommodate other specific or modified stains and/or procedures upon request.


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Hematoxylin eosin 

Masson’s trichrome

Sirius red (polarized, fibrosis)

Safranin-O

TRAP stain (osteoclasts)

Von Kossa 

PAS light green

Toluidine blue

more…

Immunohistochemistry

Immunohistochemistry (IHC) is a key tool in both early research and later stage development. We can work up (optimize) any antibody for you. We have a list of hundreds of antibodies we've already optimized and can suggest to you which antibodies to

Histology Services

Histology Services

purchase and which ones to avoid. If we haven't worked up an antibody yet, we will work with you to optimize it specifically for your specimens. We will utilize a variety of pre-treatments (heat, enzyme digestion, etc.), try different titrations of the primary antibody (from "neat" to 1:1000) at different incubation times to see what works the best. We can also try different fixatives, frozen sections or whatever it will take to have the antibody work on your tissue.

The recent antibodies list: 

Collagen I/II/IV, α-SMA, CD19, CD31, CD45, CD11b, CD68, GFAP, EGF, COX-2, Fibronectin, and more…


Histomorphometry


     All bone-specific parameters will be measured and expressed in units following the guidelines established by the ASBMR histomorphometry nomenclature committee. Using the semi-automatic mode existing in the Histology ServicesOsteomeasure system, based on ASBMR Standard Nomenclature, uses specialized measurement list to automatically calculate over 175 parameters of bone. Intelligent open measurements may be redefined for experimental, unconventional or other uses. Automatically compensates for the kinetic labelling method employed. Sophisticated Report Generator integrates independent measurements from serial sections. Sophisticated Text File Generator allows composition of text files from primary or derived data that are compatible with all common spreadsheet-based packages - allows more sophisticated or unconventional analysis. Entire system menu driven and user friendly with extensive help system and bone specific prompts and options.






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