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OVA-Induced Experimental Allergic Conjunctivitis in Mice

Allergic conjunctivitis (AC) is defined as an inflammatory response initiated by type I (IgE-dependent and mast cell mediated) and/or type IV (mediated by T cells) hypersensitivity reactions following exposure to an allergen. Binding of allergen to IgE cross-links its receptors on the surface of mast cells resulting in their degranulation and the release of inflammatory mediators, which may lead vasodilatation, increased vascular permeability and the infiltration of inflammatory cells into the conjunctiva. This process triggers the acute phase of the disease characterized by clinical manifestations and bilateral hyperaemia, chemosis, lid oedema and pruritus.

Case: Compounds on Experiment Allergic Conjunctiviti) in BALB/C mice.
Experimental Procedures

·       Animal species and strain: BALB/c mice

·       History of treatment: Naive

·       Sex, age and weight: Female, 6 - 8 weeks.

·       Food: Free access to food

·       Water: Free access to water

·       Reagent: Ovalbumin (OVA)/ Inject Alum hydroxide solution

Total Score of Hyperemia and Edema
Count of Eye Scratching


Histopathological Eosinophils Detection


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