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Bovine IRBP R16-Induced Experimental Autoimmune Uveitis

Experimental autoimmune uveitis (EAU) is an experimental animal model to study human uveitis and even systemic autoimmune diseases. Experimental autoimmune uveitis (EAU) is an organ-specific, T-cell-mediated autoimmune disease that targets the neural retina and related tissues; it is induced by immunization with retinal antigens. The pathology of EAU closely resembles human uveitic diseases of a putative autoimmune nature in which patients display immunological responses to retinal antigens. The EAU model has served as an invaluable tool to evaluate novel immunotherapeutic and conventional therapeutic strategies. The EAU model is also useful for study of basic mechanisms of tolerance and autoimmunity to organ-specific antigens in immunologically privileged sites. Thus, EAU is useful as a tool for clinical and for basic studies of ocular and organ-specific autoimmunity. EAU can be induced in susceptible animals by peripheral immunization with a number of evolutionarily well-conserved uveitogens (purified protein antigens extracted from the retina or their peptides) in adjuvant or by adoptive transfer of lymphocytes specific to these antigens.

Case: Compounds on Bovine IRBP R16-Induced EAU in Lewis Rats
Experimental Procedures

·         Animal species and strain: Lewis rats

·         History of treatment: naive

·         Food: free access to food

·         Water: free access to water

·         Reagents: IRBP R16 solution/ Modified Complete Freund’s Adjuvant (CFA)


Experimental Results

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Effect of FTY-720 on Bovine IRBP R16-Induced EAU in Lewis Rats

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Histopathology Photo

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