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Cotton-Induced Granuloma in Rats

Granuloma is a chronic inflammation model, and it is a commonly used method to evaluate the inhibitory effect of drugs on inflammation and proliferation. Cotton balls or filter paper were implanted into rats or mice to induce inflammation and observe the weight of granuloma implanted in cotton balls or filter paper. The growth of connective tissue and the formation of granulation tissue were induced by the stimulation of paper or cotton balls embedded in the subcutaneous tissue of rats, which were similar to the pathological changes in the later stage of inflammation in clinic. In addition, PharmaLegacy utilizes carrageenan, agar and other granulomatous methods, plastic ring granuloma, etc.


Data from this model is being collected.

Please feel free to contact us if you are interested in it.





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