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Myocardial Infarction Model

Myocardial infarction is a leading cause of heart failure, acute or chronic heart failure following myocardial infarction represents a major cause of morbidity, hospitalization and premature death, despite current treatment strategies. Cardiac remodelling post myocardial infarction leads to heart failure, which leads to the activation of neurohormonal systems, pro-inflammatory and pro-fibrotic cytokines. Myocyte apoptosis, hypertrophy and interstitial fibrosis and left ventricle dilation, systolic and diastolic dysfunction, and congestive heart failure.

Case Study: Rat Model of Myocardial Infarction (MI)

A clinically predictive model for acute or chronic heart failure is used to test resembling changes in physiopathology and histopathology in the development of heart failure post MI in human, and to predict responses to pharmacologic interventions in human.

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Clinical Parameters

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Echocardiograph (M mode)

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Reactive Fibrosis

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