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KLH-Induced T Cell Dependent Antibody Response (TDAR) Model

TDAR to an antigen is a comprehensive immune function assay evaluating various aspects of immune responses, including antigen processing and presentation, B and T lymphocyte interactions, antibody production; and cytokine-dependent isotype class switching. 

The use of a TDAR assay is endorsed by regulatory agencies as a "default" immune function test for evaluating the immunotoxicity potential of new drug candidates.

It is also employed to evaluate investigational drug efficacy in preclinical pharmacology studies, provide evidence of biological impact in clinical trials, and evaluate primary or secondary immunodeficiency diseases. 

Evaluation of TDAR in NHP provides excellent cross-reactivity to most human biologic drugs. Additionally, NHP testing maybe appropriate for small molecule and novel pharmaceutical agents as metabolism, drug exposure, drug clearance, and immune responses are highly homologous to human.

KLH-Induced TDAR in Cynomolgus Monkey

Animal: Cynomolgus monkeys, male 

Material: Keyhole Limpet Hemocyanin (KLH), monkey anti-KLH IgM and IgG ELISA Kit    

Kinetics of Anti-KLH IgM & IgG Response





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