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Collagen II-induced rheumatoid arthritis (RA) model

RA model developed in NHP may be highly demanded for the development of novel anti-arthritic compounds when using most modern drug technologies because of the close phylogenesis that provides the cross-reactivity between human and NHP. 

We have established a RA model induced with type II collagen in Cynomolgus monkeys. We demonstrated that the model is in response to anti-human IL-6 monoclonal antibody, anti-human-interleukin 6 receptor monoclonal antibody treatment as well as to new test articles from our collaborators. 

This model provides a valuable tool for study of human RA disease in pathogenesis, biomarkers, translational research, and most importantly for the development of novel anti-arthritic therapeutic strategy.


Collagen II-Induced Arthritis (CIA) in Cynomolgus Monkey

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Results: mRNA profile in CIA monkey

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Results: Blood biomarkers in CIA monkey

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Hematocrit and Hemoglobin vs. Arthritic Score-Anemia Association

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Effects of Anti-Human IL-6 Monoclonal Antibody on CIA in Female Cynomolgus Monkeys


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Results: X-Ray Score

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Effects of IL-6 Receptor Blocker on CIA in Female Cynomolgus Monkeys


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Results: X-Ray Score


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Results: PIP histopathology evaluation (toluidine blue staining)

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