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Lipopolysaccharides (LPS) are antigenic and adjuvant components expressed at outer membrane of Gram-negative bacteria.
Innate immune receptors recognize microorganism-specific motifs. One such receptor–ligand complex is formed between the mammalian Toll-like receptor 4 (TLR4)–MD2–CD14 complex and bacterial LPS.
LPS evoked inflammation provides a simple model to study several bacterial diseases such as sepsis.
LPS interacts with its TLR4 receptor, triggering the downstream signaling pathway to evoke inflammation. The i.v. low dose of LPS-induced cytokines expression can be a simple/fast in vivo model to investigate the effect of compound that targets any molecule in the downstream signaling pathway of LPS.
Animal: Cynomolgus monkeys, male
Material: Lipopolysaccharide (LPS)
