Oncology /Immuno-oncology Platform
Non-Human Primates Platform
Inflammation/Autoimmune Diseases Model
Metabolic/Liver/Cardiovascular Diseases Model
Animal: Cynomolgus monkeys, male
Material: Lipopolysaccharide (LPS)
In-life observation showed that all animals treated with LPS endotoxin developed extensive symptoms including loss of appetite, insensitiveness, excessive fatigue and apathy. All the clinical observation signs demonstrated the systematic inflammation was successfully induced by LPS infusion including high body temperature, increased heart rate and decreased SpO2.
LPS induced liver and kidney function impairments in all animals were reflected by increased serum levels of ALT, AST and BUN.
Following LPS infusion, APTT and PT showed delay in time at all time points measured in blood plasma compared to the baseline (heathy status). Fibrinogen levels increased continuously starting 12 hours after LPS administration in both groups.