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Our Service
Exakt® Histological System

PharmaLegacy (PL) provides contract histology, immunohistochemistry and pathology services to the biopharmaceutical and medical device industry. Whether preparing a single biopsy or a complete study, PL offers high-quality slide preparation, pathological evaluation and report preparation in a timely and cost-effective manner. Our team of highly trained and experienced board-certified veterinary pathologists, skilled and detail-oriented technical personnel and full-time quality assurance staff are committed to providing the highest level of quality. All PL studies are conducted within our laboratories, under the direct supervision of our pathologists, quality assurance unit and PhD-level scientific managers. For preparation of histology and pathology studies for regulatory submission, PL follows FDA, OECD, and CFDA guidelines. 


Regulatory Histopathology

Our histopathology team provides expert contract histology slide preparation and regulatory pathology evaluation of tissues from both supporting GLP and non-GLP toxicology studies, pharmacology and efficacy studies, basic research and diagnostics. Our clients include pharmaceutical, biotechnology and medical device companies, universities, grant funded organizations, and basic researchers.    


Sections 


Frozen Sections

We have the modern cryostat and have the capabilities of sectioning almost any type of specimen, including mouse bone sections. We can section and mount your specimens to custom orders. 


Paraffin Sections

Most of our work is the routine processing and embedding to paraffin block and we offer many options in this service. To save yourself time, you can trim the tissues and place them in your own labeled processing cassettes. You can even perform your own processing and paraffin infiltrating and embedding and ask us just to do the sectioning. For quality slides please use our services followed the proper trimming technique, correct processing solutions and infiltrating and embedding paraffins and processing schedules. 


Plastic Sections

Plastic sections are used for the evaluation of non-decalcified bone, devices such as stents or bone pins and implanted material such as suture. Hard biological tissue, such as bone and tissue containing metal can be embedded in plastics, sectioned with a low-speed saw and either ground to a thickness suitable for histological examination or sectioned with a tungsten knife. 

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Histochemical Stains

The PL histology laboratory is skilled in the histologic preparation of a large variety of histopathology and special stains on frozen, paraffin and plastic embedded tissues from a range of both common and unusual research and discovery models. We can accommodate other specific or modified stains and/or procedures upon request.

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Immunohistochemistry

Immunohistochemistry (IHC) is a key tool in both early research and later stage development. We can work up (optimize) any antibody for you. We have a list of hundreds of antibodies we've already optimized and can suggest to you which antibodies to purchase and which ones to avoid. If we haven't worked up an antibody yet, we will work with you to optimize it specifically for your specimens. We will utilize a variety of pre-treatments (heat, enzyme digestion, etc.), try different titrations of the primary antibody (from "neat" to 1:1000) at different incubation times to see what works the best. We can also try different fixatives, frozen sections or whatever it will take to have the antibody work on your tissue. The recent antibodies list: Collagen Ⅰ/Ⅱ/ Ⅳ, α-SMA, CD19, CD31, CD45, CD11b, CD68, GFAP, EGF, COX-2, Fibronectin, and more…

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