Bone Models Bone Metabolism

 IN VIVO MODELS

 

Mouse
  • Calvaria periosteal injection for assessing effects on bone formation or resorption capability or both
  • Dietary alterations for body composition and bone mineral density
  • Estrogen-deficient bone loss for screening anti-resorption or anabolic agents
  • Steroid-induced bone loss for seeking agents of osteopenia antagonist
Rat
  • Bone safety for evaluating therapeutic effects on skeletal integrity, short or long term.
  • Disuse bone loss for examining anti-resorptive and anabolic agents.
  • Dietary alterations for body composition and effects on bone mineral density.
  • Estrogen deficient bone loss for screening anti-resorptive and anabolic agents.
  • Steroid-induced bone loss for seeking agents of osteopenia antagonist.
  • Testosterone deficient bone loss for screening anti-resorptive and anabolic agents.
Non-Human Primate
  • PD/PK of dose range and short term effects on biomarkers of bone.
  • Estrogen deficient bone loss for screening therapeutic effects on biomarkers of bone.
  • Bone safety for evaluating therapeutic effects on skeletal integrity, long term with biopsies.

 EX VIVO PROCEDURES

  • Biomechanics of bone properties
  • Serum and urine biomarkers of bone remodeling
  • Densitometry using pDEXA, and pQCT on bone mineral, micro-CT of 3-D structures
  • Static and dynamic histomorphometry of bone cells and tissue, and quality of bone matrix