Services

Services

Inflammation/Immune Diseases

We have collected and validated virtually all widely used industry protocol models available, and work to meet international standards in both consistency and accuracy. Our animal models, such as Asthma, Rheumatoid Arthritis, Colitis, DTH, etc... and established experimental procedures are validated according to proven industry benchmarks.   



  Asthma 

         - Ovalbumin-induced in rats and mice 


  Allergic Rhinitis  

         - OVA-induced allergic rhinitis in mice 


  Acute Lung Inflammation 

         - LPS-induced acute lung inflammation in rats and mice  


  Comedones 

         - Oleic acid-induced comedones in rabbits 


  Cough 

         - Capsaicin-induced cough in guinea pigs 

         - Citric acid-induced cough in guinea pigs 


  Colitis 

         - DSS-induced colitis in mice 

         - DNBS-induced colitis in rats 

         - Chemotherapeutics induced colitis in rats 


  Delayed Type Hypersensitivity (DTH) 

         - Oxazolone-induced DTH in mice 

         - DNFB-induced DTH in rats and mice 

         - Tetanus toxoid-induced DTH in monkeys 


  Experimental Autoimmune Encephalomyelitis (EAE) 

         - MBP-induced EAE in rats 

         - MOG-induced EAE in mice 

         - PLP-induced EAE in mice 

         - Cuprizone induced demyelination in mice 


  Experimental Autoimmune Neuritis (EAN) 

         - SP-26-induced EAN in rats 


  Experimental Autoimmune Uveoretinitis (EAU) 

         - Bovine IRBP R16-induced EAU in rats 


  Graft-Versus-Host Disease (GVHD) 

         - Allobone marrow transplantation induced acute GVHD in mice 


  General Inflammation 

         - Arachidonic acid-induced ear edema in ICR mice 

         - Croton oil-induced ear edema in ICR mice 

         - Phorbol ester-induced ear edema in ICR mice 

         - Carrageen-induced paw edema in mice 

         - Testosterone induced benign prostatic hyperplasia 

         - Acetic acid induced pain in mice 

         - Cecal ligation and puncture induced sepsis in mice 


  LPS-induced Cytokine Production 

         - LPS-induced cytokine production in mice 

         - LPS-induced cytokine production in monkeys 


  Lung Fibrosis 

         - Bleomycin-induced lung fibrosis model in rats 


  Passive Cutaneous Anaphylaxis (PCA) 

         - PCA in rats and mice 


  Rheumatoid Arthritis 

         - Adjuvant-induced arthritis in rats 

         - Collagen II-induced arthritis in rats and mice 

         - Collagen II-induced arthritis in monkeys 


  System Lupus Erythematosus (SLE) 

         - SLE in NZB/W F1 mice 

         - SLE in MRL/lpr mice 


  Gouty Arthritis 

         - MSU-induced gouty arthritis in rats 


  Psoriasis-like inflammation 

         - IL-23-induced psoriasis-like inflammation in mice 

         - Imiquimod induced psoriasis-like inflammation in rats 


  Radioprotective activity in rats and mice   

         Integrated Drug Evaluation 

         - Cell-based Assays                                                        

         - Clinical scoring 

         - Clinical Biochemical Analyzer                                       

         - Cytokine panel analysis 

         - Complete blood count (CBC)                                        

         - PK/PD Studies 

         - Immunohistochemistry/Histopathology