Technotes

Technotes

Osteoarthritis

About the Disease


Osteoarthritis (OA) also known as degenerative joint disease. The degradation of joint includes articular cartilage fibrillation, fissure and partial erosion, full thickness loss of articular cartilage and ends with bone exposed. Symptoms include joint pain, swelling and reduced motion in joints. It can occur in any joint, but usually it affects hands, knees, hips or spine. A variety of causes—hereditary, developmental, metabolic, and mechanical—may initiate processes leading to loss of  cartilage. OA is the most common form of arthritis, and the leading cause of chronic disability. It affects about 40 million people in the United states. 

Current Treatment


Cartilage has limited ability to repair itself because it doesn't have a blood supply. Medications can help control the pain of OA but nothing can stop the disease process, nor is there an effective way to repair damage that has occurred. In the last decade different surgeries such as autologous chondrocyte implantation (ACI) have been used in clinic. The reparative tissue produced after most cartilage repair techniques can appearnormal grossly and even under light microscopy, but cannot withstand the demands required of an articular surface and quickly degenerate (Dr. Buckwalter). If pain becomes debilitating, joint replacement surgery may be used to improve the quality of life. Therefore, osteoarthritis treatment/cartilage repairing is still a big challenge.

Osteoarthritis Animal Model Available at PharmaLegacy




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