Osteoarthritis (OA) also known as degenerative joint disease. The degradation of joint includes articular cartilage fibrillation, fissure and partial erosion, full thickness loss of articular cartilage and ends with bone exposed. Symptoms include joint pain, swelling and reduced motion in joints. It can occur in any joint, but usually it affects hands, knees, hips or spine. A variety of causes—hereditary, developmental, metabolic, and mechanical—may initiate processes leading to loss of cartilage. OA is the most common form of arthritis, and the leading cause of chronic disability. It affects about 40 million people in the United states.
Cartilage has limited ability to repair itself because it doesn't have a blood supply. Medications can help control the pain of OA but nothing can stop the disease process, nor is there an effective way to repair damage that has occurred. In the last decade different surgeries such as autologous chondrocyte implantation (ACI) have been used in clinic. The reparative tissue produced after most cartilage repair techniques can appearnormal grossly and even under light microscopy, but cannot withstand the demands required of an articular surface and quickly degenerate (Dr. Buckwalter). If pain becomes debilitating, joint replacement surgery may be used to improve the quality of life. Therefore, osteoarthritis treatment/cartilage repairing is still a big challenge.
About PharmaLegacy Services
• World-class quality with increased speed and output at competitive cost.
• International GLP and QA-based operation.
• Electronic data management system (BioBook) for quality execution and maximum IP protection.
• AAALAC accredited large capacity to house over 10,000 animals under SPF and conventional conditions.
• Availability of 10,000 non-human primates for research use.