ONCOLOGY
Specialty Services
Oncology
Tumor Biology and Molecular Pharmacology
- Angiogenesis
- Aortic ring explant assay
- Cell migration assay
- Tube formation assay
- VEGFR2 kinase assay
- Metastasis Assays
- Malignant cell invasion assay
- Proliferation
- MMT, SRB, and XTT assays
- Biology techniques
- RT-PCR, Western, ELISA, FACS
- Ex vivo pharmacology
- Tissue necropsy and process
- RT-PCR, Western, ELISA, kinase activity
- Histology
- Histopathology
- Immunohistochemistry
Subcutaneous Xenograft Models
- Breast Cancer
- Kidney Cancer
- Ovary Cancer
- Brain Tumor
- Leukemia
- Pancreatic Cancer
- Cervical Cancer
- Liver Cancer
- Pharynx Cancer
- Colonrectal Cancer
- Lung Cancer
- Prostate Cancer
- Endometrial Carcinoma
- Lymphoma
- Rhabdomyosarcoma
- Epidermoid Carcinoma
- Myeloma
- Urinary Bladder Cancer
- Fibrosarcoma
- Melanoma
- Gastric cancer
- Osteosarcoma
Orthotopic Xenograft Models
Special focus on GI tract cancer:
Additional expertise in breast, kidney, spleen, prostate and brain orthotopic implantation.
Special Tumor Models
- Metastasis models
- Experimental metastasis models
- Spontaneous metastasis models
- Nude rat models
- (Combinational PK-PD study and local drug delivery)
- Orthotopic xenograft model
- Subcutaneous xenograft model
- Angiogenesis models
- Matrigel plug
- Skinfold chamber test
- Cancer imaging system
Human Primary Tumor Models
- Derived from Chinese tumor patient
- Major tumor types in Asia
- Focus on hepatocellular carcinoma, colon cancer and gastric cancer as well as pancreatic cancer and gallbladder cancer
- Strong potentials for scale-up
Adjacency Services
PK/ADME Studies
- PK/TK sample analysis (LC-MS/MS)
- PK property characterization (F, T1/2, Cmax, Tmax, CL, Vss, AUC)
- Dose proportionality • Assessment of hepatic first pass effect and biliary excretion
- PK/PD relationship • Metabolic stability (microsomes, S9 and hepatocytes)
- CYP inhibition (IC50, Ki) for DDI • CYP reaction phenotyping
- Plasma protein binding assay
- Plasma stability evaluation
Preliminary Toxicity Assessment
- Sub-acute 7-day and 14-day tox studies
- LD50 and MTD study
- Dermal toxicity (rabbits)
- Blood chemistry and histology
- Liver toxicity
PharmaLegacy Laboratories (Shanghai) Co., Ltd.
Building 7, 388 Jialilue Road ,Zhangjiang High-Tech Park ,Shanghai, China 201203
Copyright 2010.Pharmalegacy Laboratories.All Rights Reserved
Building 7, 388 Jialilue Road ,Zhangjiang High-Tech Park ,Shanghai, China 201203
Copyright 2010.Pharmalegacy Laboratories.All Rights Reserved