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2018 - 03 - 05
Immuno-Oncology IntroductionImmuno-therapy has now been representing a significant paradigm shift in cancer treatment after the promising clinical data from the immune-checkpoint m...
2018 - 03 - 02
Gastric Carcinoma     Introduction     Gastric carcinoma remains a common disease with a dismal prognosis. It represents the fourth most frequent mali...
2018 - 03 - 02
With 655,000 deaths worldwide per year, colorectal cancer (CRC) is the second leading cause of cancer-related death in Western society and the incidence and mortality are increasing dramatically in th...
2018 - 03 - 01
Asthma is a chronic inflammatory disorder of the airways in which many infiltrating cells (such as mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, and epithelial cells) and cellular ...
产品名称: Immuno-Oncology
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时间: 2018 / 03 / 05
Immuno-Oncology IntroductionImmuno-therapy has now been representing a significant paradigm shift in cancer treatment after the promising clinical data from the immune-checkpoint modulators. Profiling anti-cancer drug candidates with clinical relevant animal models provides fundamental information for oncology research and development. PharmaLegacy offers comprehensive oncology and immuno-oncology drug discovery platform which includes in vi...
产品名称: Gastric Carcinoma
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时间: 2018 / 03 / 02
Gastric Carcinoma     Introduction     Gastric carcinoma remains a common disease with a dismal prognosis. It represents the fourth most frequent malignancy and second leading cause of caner-related death worldwide. A significant geographic variation exists with high-risk areas including Japan, Central and South America and Eastern Asia. Despite the major improvements in diagnosis and treatment, less than 20% of patients survive to 5 years. Chemo...
产品名称: Colorectal Carcinoma
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时间: 2018 / 03 / 02
With 655,000 deaths worldwide per year, colorectal cancer (CRC) is the second leading cause of cancer-related death in Western society and the incidence and mortality are increasing dramatically in the rest of the world. Approximately 25% of  patients have a family history of CRC, suggesting a genetic contribution, common exposures among family members or a combination of both. Other risk factors for CRC include diet, use of non-steroidal anti-inflammatory drugs (NSAIDs), postmenopausal hor...
产品名称: Asthma
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时间: 2018 / 03 / 01
Asthma is a chronic inflammatory disorder of the airways in which many infiltrating cells (such as mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, and epithelial cells) and cellular elements play critical roles. This inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and cough usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. The inflammation also causes an assoc...
时间: 2018 / 01 / 31
Human Cancer Cell Selection PanelApplication:Human cancer cell selection panel serves for anti-cancer drug discovery. To evaluate the potential cytotoxicity and growth-inhibition effects of the test articles against multi-type tumors in a quick and efficient way. More than 60 human cancer cells can be screened by cell proliferation/cytotoxicity assay, covering Liver, Lung, Breast, Lymphoma, Colon, Melanoma, Leukemia, Myeloma tumors. After the in vitro screen, the most sensitive cancer cell lines...
时间: 2018 / 01 / 31
Hepatocellular Carcinoma            Introduction          Aflatoxin or chronic infection with hepatitis B and C virus is the predominant risk factor for HCC in Southeast Asia and Africa,     while chronic infection with hepatitis C virus and hepatic cirrhosis (mostly alcoholism) are the predominant risk factors for HCC in Western countries and Japan.  &...
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时间: 2018 / 03 / 02
Delayed Type Hypersensitivity     Introduction     Delayed type hypersensitivity (DTH), also known as cell mediated immune memory response or type IV hypersensitivity is characterized by erythema and induration at the site of contact in sensitized humans or animals. It is involved in the pathogenesis of many infectious diseases (tuberculosis, leprosy, blastomycosis, histoplasmosis, toxoplasmosis, leishmaniasis, etc.), autoimmune disease...
产品名称: Rheumatoid Arthritis
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时间: 2018 / 03 / 05
Rheumatoid Arthritis        Introduction        Rheumatoid arthritis (RA) is a systemic inflammatory disorder characterized by chronic inflammation of the synovium, which over time results in damage to the joints, leading to pain and disability. It occurs in approximately 1% of adults, and approximately 2.5 times more women than men are affected. Immune factors involved in the progression of RA are mainly manufactured by CD4+ T cells, monocytes, ...
产品名称: Osteoarthritis
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时间: 2018 / 03 / 05
Osteoarthritis         Introduction         Osteoarthritis (OA), known as degenerative joint disease, involves both articular cartilage and subchondral bone. The progression of the diseased joint includes articular cartilage fibrillation, fissure and partial erosion, full thickness loss of articular cartilage and ends with bone exposed, and sclerosis of subchondral bone. Symptoms include joint pain, swelling and reduced motion in angle and extent...
产品名称: Bone Safety
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时间: 2018 / 03 / 04
Bone Safety         Bone Structure         A.Align to biomechanical loading         Anatomical structure of bones depends mainly on the genetic and biomechanical influences to their length, width, shape and contour, and strength. In general, mechanical rules, structure alignment streams along the loading axis.         B.Cortex and trabecular         Bone has cortical shell...
产品名称: Orthopedics
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时间: 2018 / 03 / 04
Orthopedics     Introduction     Orthopedics corrects injuries or disorders of the skeletal system and associated muscles, joints and ligaments. Modern technologies in tissue engineering have revolutionized tissue and organ repairs for recovery of function. Combinations of stem cells, small molecules and biologics in biocompatible scaffold are used to restore structural and functional deficit in bone, cartilage, facet joints, intervertebral disc,...
产品名称: Bone & Osteoporosis
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时间: 2018 / 03 / 04
Bone & Osteoporosis          Introduction     Bone provides protection to visceral organs, storage of minerals, locomotive movement and are the locations of hematopoiesis. Structural integrity of bone can be affected by factors of aging, dietary imbalance, disuse, environmental contamination, infections, medicine, metabolic disorders, physical loading, radiation, smoking and trauma. Efficacy and safety ...
产品名称: Histology Services
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时间: 2018 / 03 / 05
Histology ServicesIntroduction     PharmaLegacy (PL) provides contract histology, immunohistochemistry and pathology services to the biopharmaceutical and medical device industry. Whether preparing a single biopsy or a complete study, PL offers high-quality slide preparation, pathological evaluation and report preparation in a timely and cost-effective manner. Our team of highly trained and experienced board-certified veterinary pathologists, skilled and detail-oriented ...
产品名称: DMPK Services
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时间: 2018 / 03 / 05
DMPK ServicesPharmaLegacy Models and Research ToolsPharmaLegacy can provide a complete complementary PK/ADME service. Our team of DMPK scientists are dedicated to both discovery and development. This coupled with state-of-the-art instrumentation and supported by an AAALAC accredited vivarium, assists our clients from lead candidate selection through development and ensures a high quality of DMPK studies with cost-efficiency and fast turnaround.Case Study 1 - PK Profiling in Rodent, Non-human Pri...
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时间: 2018 / 03 / 06
Collagen Induced Arthritis in Monkey         Introduction         Rheumatoid arthritis (RA) is a systemic inflammatory disorder characterized by chronic inflammation of the synovial membrane, which over time results in damage to the joints and leads to pain and disability. Rodent models with collagen II induced arthritis (CIA) have been extensively used in academic research and pharmaceutical industry for investigating pathogenesis RA and its tre...
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时间: 2018 / 03 / 05
T-cell-Dependent Antibody ResponseInduced by KLH in Cyno’sIntroduction     1.TDAR to an antigen is a comprehensive immune function assay evaluating various aspects of immune responses, including antigen processing and presentation, B and T lymphocyte interactions, antibody production and cytokine-dependent isotype class switch (i.e., IgM to IgG specific antibody response).     2.The use of a TDAR assay is therefore endorsed by regulatory agencies...
时间: 2018 / 02 / 02
Inflammatory Bowel DiseaseIntroductionInflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory condition of the gastrointestinal tract that is usually manifest as 1 of 2 distinct, but sometimes overlapping clinical entities; ulcerative colitis (UC) and Crohn’s disease (CD). While CD is a multifocal, transmural inflammatory process that can affect any part of the digestive tract, UC is characterized by a superficial, continuous inflammation, which is limited to the large...
产品名称: Multiple Sclerosis
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时间: 2018 / 03 / 04
Multiple Sclerosis         Introduction         Multiple sclerosis (MS), also known as disseminated sclerosis, is an autoimmune condition with demyelination of central nerves often resulting in physical and cognitive disabilities in many patients. It has a prevalence of 2 to 150 per 100,000 in the population,  usually occurring in young adults and females.                       ...
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时间: 2018 / 03 / 04
Liver Fibrosis and Cirrhosis                  Introduction         Liver fibrosis results from chronic injury such as viral hepatitis (especially hepatitis B and C), alcohol abuse, drugs, metabolic diseases due to overload of iron or copper, congenital abnormalities or autoimmune attack of hepatocytes or bile duct epithelium. It is characterized by the encapsulation or replacement of injured tissue by a collagenous scar. ...
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