---
title: "Glaucoma / Neuroprotection"
canonical: "https://www.pharmalegacy.com/indications/ophthalmic-disease-models/glaucoma/"
lastmod: "2026-02-01T15:18:04+00:00"
generator: "llm-mirrors/1.0.19"
---

Professional brass musicians, when performing prolonged high-pitched notes at high volumes, subject their eyes to a significantly increased intraocular pressure. The forcible exhalation against a closed glottis, also known as the valsalva maneuver, creates a sharp increase in intrathoracic and abdominal pressure, which ultimately decreases the blood flow back from the neck and head, leading to an increased intraocular pressure.
Multiple studies have theorized a correlation between playing high-resistance wind instruments and glaucoma. However, patients already suffering from glaucoma are advised to steer away completely from high-resistance wind instruments, as playing them might exacerbate their condition. Now imagine a world where Louis Armstrong or Charlie Parker had glaucoma. A world where Armstrong would have to put his trumpet down, and Parker his saxophone, for a condition that with your pipeline and our models at PharmaLegacy, can potentially be cured. Get in touch with one of our experts and let us join efforts; we have the knowledge and models to move your glaucoma and optical neuroprotection pipeline forward.