OCULAR INFLAMMATION MODELS
Critical ocular inflammation studies call for the best in vivo models.
Ocular inflammation has multiple etiologies, ranging from contact lens wear, trauma and allergens to dietary and lifestyle changes. Even though the triggers of ocular inflammation are numerous, the symptoms produced are all similar, given that they all ultimately induce the same immunological cascade. This partially explains why most treatments of different types of ocular inflammation are almost identical.
The gap in ocular inflammation studies is therefore the lack of targeted treatments for each underlying etiology. This is where your studies and our expertise in pharmacology comes into play. Get in touch with one of our experts now and let’s discuss things further.
MODELS / SERVICES
Case: Compounds on Bovine IRBP R16-Induced EAU in Lewis Rats
Experimental Procedures
· Animal species and strain: Lewis rats
· History of treatment: naive
· Food: free access to food
· Water: free access to water
· Reagents: IRBP R16 solution/ Modified Complete Freund’s Adjuvant (CFA)
Experimental Results
Effect of FTY-720 on Bovine IRBP R16-Induced EAU in Lewis Rats
Histopathology Photo
Case: Compounds on Experiment Allergic Conjunctivitis in BALB/C mice.
Experimental Procedures
· Animal species and strain: BALB/c mice
· History of treatment: Naive
· Sex, age and weight: Female, 6 – 8 weeks.
· Food: Free access to food
· Water: Free access to water
· Reagent: Ovalbumin (OVA)/ Inject Alum hydroxide solution
Total Score of Hyperemia and Edema
Count of Eye Scratching
Histopathological Eosinophils Detection
Enforcing quality:
- Rigorous adherence to international GLP and QA best practices
- 1000+ validated animal models of disease spanning 40+ diseases
- FDA Part 11 compliant
- PK/PD, molecular pharmacology and preliminary toxicology adjacency studies
Commit to a CRO that can meet your expectations, and more. Work with PharmaLegacy.
Top Pharmaceutical Companies Trust PharmaLegacy For Their Preclinical Ophthalmology Studies
Your preclinical ophthalmology studies call for flawless and affordable ophthalmology models. Download our Ophthalmology brochure and see how our models and decades of expertise can give you the clarity you need in your pipeline.
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