Preclinical Ophthalmology CRO

No animal study can predict with certainty how an ophthalmology therapy will perform in human subjects, but with over 1500 validated models, PharmaLegacy ensures they come as close as possible.

Start Your Ophthalmology Study Now

Why wait months to start your study? PharmaLegacy’s ophthalmology models are maintained for ready availability so we can start your study in just two weeks!

Your data can’t be any better than your models or the people who run your studies. PharmaLegacy has been developing models for decades, rigorously validating each one. Our scientists average 15 years of professional scientific experience and 5 years with PharmaLegacy. There is a good reason why 12 of the top 20 pharmaceutical companies trust PharmaLegacy. You can expect more when you choose PharmaLegacy as your ophthalmology CRO.

Our Ophthalmic Disease Models & Services Include:

  • Laser-induced Choroidal Neovascularization (CNV)
  • DL-AAA-induced Retinal Neovascularization and Leakage
  • VEGF-induced Retinal Leakage
  • Oxygen-Induced Retinopathy (OIR)
  • HUVEC Tube Formation Assay
  • Choroid Sprouting Assay
More Info on Wet AMD Models
  • Blue Light / Bright White Light-induced Retinopathy
  • MNU-induced Retinal Degeneration
  • Oxidative Stress Induced Geographic Atrophy
  • Sodium Iodate Induced RPE / Retinal Degeneration
  • C3 humanized mice available
More Info on Dry AMD/GA Models
  • STZ Induced Diabetic Retinopathy
  • CA-I Induced Retinal Edema
  • DL-AAA-induced Retinal Neovascularization and Leakage in rabbit
  • VEGF-induced Retinal Leakage
  • Oxygen-Induced Retinopathy (OIR)
  • HUVEC tube formation assay
More Info on Diabetic Retinopathy / Diabetic Macular Edema Models
  • Two-stage laser induced subretinal fibrosis (mouse)
  • Proliferative vitreoretinopathy (PVR) (rabbit)
  • Central/branch retinal vein occlusion (rodent)
  • Acute Intraocular Hypertension
  • Chronic Intraocular Hypertension
  • NMDA Induced Retinal Ganglion Cell (RGC) Damage
  • Optic Nerve Clamping-induced RGC Damage
  • Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
More Info on Glaucoma Models
  • Allergic Conjunctivitis
  • Conjunctivitis Induced by Staphylococcal Infection
  • Graves’ Orbitopathy
  • Neuromyelitis optica spectrum disorders (in development)
  • Experimental Autoimmune Uveoretinitis (EAU) in Mouse / Rat
  • Endotoxin-induced Uveitis (EIU)
  • Ovalbumin (OVA)-induced Experimental Allergic Conjunctivitis (EAC)
More Info on Ocular Inflammation
  • Benzalkonium Induced Dry Eye
  • Scopolamine + Low Humidity Induced Dry Eye (Mouse)
  • Corneal Epithelial Damage
  • Corneal Neovascularization Induced by Stitching / NaOH Burn (Rabbit)
  • Ocular Pain Test
More Info on Ocular Surface Disorder Models
  • Cataract Model in Rats
  • Spontaneous Cataract Cyno Monkeys
  • Inherited Retinal Disease Models
  • CAG-LSL-ZsGreen Reporter Mice
  • Colony management and phenotyping
  • Multiple routes of administration
  • Functional assessment
  • Multiple retinal markers validated
  • Confocal microscopy
  • Tissue distribution assay
More Info on Ocular Gene Therapy Studies
  • Myopia
  • Presbyopia
  • ADC induced cornea complications
  • Drug induced ocular complications
  • Tolerability/GLP-like TOX assessment
  • SPOTS Scoring System
  • Ocular PK
START YOUR Ophthalmology STUDY NOW

Comprehensive Capabilities for Demanding Ophthalmology Studies

Delivering results in ophthalmology studies isn’t only about having a world-class selection of models. It’s also about having the expertise and capabilities to use them to maximum effect. PharmaLegacy can offer any necessary dosing schedule and administration method (anterior chamber injection, intravitreal injection, retrobulbar injection, subretinal injection, suprachoroidal injection, eye drop, etc.). We also are equipped to perform a wide range of ophthalmic examinations, including:

  • Color / IR / Red-free Fundus Photograp
  • Corneal Fluorescein Staining, Photographing & Scoring
  • Direct / Indirect Ophthalmoscopy
  • f-ERG / f-VEP / c-wave / PhNR
  • Intraocular Pressure (IOP)
  • Fundus fluorescence angiography (FFA)
  • Spectral Domain Optical Coherence Tomography (SD-OCT)
  • Slit-lamp Examination & Photographing
  • Tear Secretion Measurement
  • Optomotor Response (OMR)
  • and more

START YOUR OPHTHALMOLOGY STUDY TODAY

    When you choose PharmaLegacy as your preclinical ophthalmology CRO, we aspire to get you the most clinically relevant data at a price you can afford and on a timeline that puts your pipeline at an advantage.

    Why wait months to start your ophthalmology study? We maintain ready availability of all of our advertised models and can usually begin a study in under two weeks!

    With our massive catalog of over 1500 readily available models, our scientific staff averaging over 15 years of experience, and our surprisingly affordable pricing, when you choose PharmaLegacy as your preclinical ophthalmology CRO, you can expect more.