Bone Metastasis

Pushing the Boundaries of Therapeutic Interventions

Bone metastases, whether osteolytic or osteoblastic in nature, typically spread to the spine, pelvis, skull, and long bones. By the time skeletal-related events start to manifest – be it pathological fractures, spinal compression, hypercalcemia or more – patient outcomes are already grim: to this day, bone metastases still lack a cure.The urgency for novel bone and orthopedic models has never been greater. With cancers such as melanoma, breast cancer, and colon cancer frequently metastasizing to the bones and drastically reducing survival rates, innovative treatment strategies are imperative. Over 100,000 cases of bone metastasis are diagnosed annually, underscoring the critical need for cutting-edge research and accelerated therapeutic development.At PharmaLegacy, our team of experts is relentless in its efforts to help you better understand bone metastasis, and ultimately, put a stop to it. With your pipelines and our decades of expertise, let’s stop metastases in their tracks.

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Bone Metastasis

Bone Metastasis Models and Research Tools

Injection Methods Strengths Weaknesses Model Availability
Orthotopic Inoculation

  • Mammary fat pad
  • Other primary sites
  • Study tumor growth in situ and distant metastases
  • Mimic human disease progression
  • Unstable bone metastasis rate (40-60%)
  • MDA-MB-231
  • 4T1
  • & More
Blood Stream:

  • Left cardiac ventricle
  • Intra-arterial
  • Intravenous
  • Study circulation and metastases
  • Produces metastases easily
  • Good for investigating tumor cell homing and interactions with bone microenvironment
  • Requires technical skills
  • Potential multi-organ metastases
  • MDA-MB-231
  • 4T1
  • PC-3
  • & More
Intra-osseous Injection:

  • Intra-tibial
  • Intra-femur
  • Convenient and reproducible development of metastases
  • High tumor take rate in bone
  • Useful for studying genetic manipulation
  • Does not reflect complete course of tumor metastasis
  • MDA-MB-231
  • 4T1
  • RM1
  • RPMI8226
  • & More

MODELS / SERVICES

IVIS Imaging

VIS Imaging

H&E/TRAP Staining

Pain Measurement

Biomarker Analysis

IVIS® Spectrum

X-Ray

Histopathology Expertise

Von Frey Test/Radiant Heat Beam Test

FACS/In Vitro Platform

Committed to quality:

  • 380,000 ft2 facility with 120,000 ft2 of SPF and conventional vivarium to house 30,000 rodents and large animals
  • Capacity to run 200 animal studies concurrently while strictly following AAALAC and ILAC guidelines
  • Web-based live video streaming allows remote monitoring of operations from any location worldwide
  • Operations structured for maximum protection of clients’ work and intellectual property
  • 24/7 access to PharmaLegacy representatives
  • Hundreds of FDA / CFDA IND filings

When fighting the devastating impact of bone metastasis, you need a partner with proven expertise and advanced preclinical solutions. PharmaLegacy can be that partner. Get in touch now, and together, let’s drive the breakthroughs that could transform metastatic cancer treatment.

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Top Pharmaceutical Companies Trust PharmaLegacy For Their Bone Metastasis Studies

Creating novel bone and orthopedics models needs no justification in a world where new pathologies are constantly appearing and even evolving, especially when a large number of cancers metastasize to the bones.Download the brochure to learn more about our Bone Metastasis Models.

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