Xenograft mouse models are mainly used to assess the multiple factors involved in the development of malignant tumors (transformation and invasion), how they metastasize, and their response to different types of treatments. The advantages of using xenograft models are too many to be listed, but some noteworthy examples are the simplicity of the grafting technique, the preservation of both tumor heterogeneity and lineage hierarchy, and the possible future applications in personalized precision medical treatments.

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