Metabolic dysfunction-associated steatohepatitis (MASH) MODELS
Delivering translatability in MASH studies.
Metabolic dysfunction-associated steatohepatitis (MASH), previously known as nonalcoholic steatohepatitis (NASH), is distinguished from other hepatic disorders by hepatocyte ballooning and degeneration as well as lobular inflammation which can eventually deteriorate into liver fibrosis. If it remains untreated, MASH can develop into cirrhosis, and in some instances, hepatocellular carcinoma (HCC).
The biggest challenge in MASH preclinical studies is finding an animal model that provides your pipeline with enough similarity to the human disease state and translatability into clinical applications. Our MASH models at PharmaLegacy offer you with a well-rounded choice that ultimately depends on the facet of MASH your study is tackling. Not sure which model suits you best? Contact PharmaLegacy and our experts will give you the answers you need.
MODELS / SERVICES
Study Outline
· Male Wistar rats
· Animals were fed an MCD diet for a period of 8 weeks to establish the MASH model
· Animals were treated with vehicle or reference throughout the entire 8-week study
Treatment Groups
Body Weight, Liver Weight
Food intake per rat per day
Serum Levels of ALT (U/L);AST (U/L) and Total Bilirubin(U/L)
H & E Staining (MCD Treated Group)
Sirius Red Staining (MCD Treated Group)
MCD Rat Model Development - Body Weight and Food intake and Relative Liver Weight
MCD Rat Model Development - Serum levels of ALT and AST
MCD Rat Model Development - H&E staining in MASH
STZ-HF Mice Study - Serum Levels of ALT, AST and Glucose
STZ-HF Mice Study - Serum Levels of TC, TG, LDL-C and HDL-C
STZ-HF Mice Study - Histopathology in MASH
STZ-HF Mice Study - Histopathology in MASH
HF-CCl4 Mice Study – Biochemical Data, Liver weight and Hepatic TG
HF-CCl4 Mice Study - Histopathology in MASH
The Capabilities to Succeed:
- Research data electronically managed by BioBook (IDBS, UK)
- Rigorous adherence to international GLP and QA best practices
- FDA part 11 compliant
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