The bridge between oncology and toxicology.

Rat models come with a set of advantages over mice models: they are physiologically more similar to humans, they are large in size which makes them more amenable for different kinds of research (namely imaging and surgical manipulation), and they have significant advantages in memory and cognition research. The nude rat model is one of the main immunodeficient rat models that are available to researchers. They have greatly reduced T cell levels, which allows them to accept xenografts from humans.

The main advantage of using rat models is their ability to bridge both oncology and toxicology studies. Among the available nude rat models at PharmaLegacy are the orthotopic solid tumor models, and the subcutaneous models (more under development). Contact PharmaLegacy, and let us pave the way to the success of your pipeline.

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Nude Rat Models


Case Study:

HCCLM3 Orthotopic Implantation Model in Nude Rats


Case Study:

HCCLM3 s.c. Xenograft Model in Nude Rats


Animal: 12 nude rats, 5~6 weeks, male & female

Tumor resource: T1, 3mm*3mm*3mm/rat, subcutaneous implantation

Grouping: When tumor volume reaches 200 mm3

The capability to succeed:

  • FDA part 11 compliant
  • AAALAC accredited vivarium
  • PK/PD, molecular pharmacology and preliminary toxicology adjacency studies
  • 1000+ validated animal models of disease spanning 40+ diseases

PharmaLegacy will accelerate your success with no compromise to the quality of your pipeline. You’ve come to the right place. Contact us now.

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Top Pharmaceutical Companies Trust PharmaLegacy for their Oncology Trials

“The study they delivered on a very reasonable budget was top notch […] The model was executed flawlessly.”

See why a top-20 pharmaceutical company trusts PharmaLegacy for their preclinical immuno-oncology trials.

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