Delivering translatability in autoimmunity models.

Uveitis and conjunctivitis can both lead to worrisome ocular complications. Synechia, retinal scarring, and spreading of the infection to the cornea, lids, and tear ducts are some of the many exacerbations that untreated uveitis and conjunctivitis can potentially develop into. Certain autoimmune diseases, namely Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) happen to have ocular manifestations in their early presentations, which further justifies the search for accurate and translatable uveitis and conjunctivitis models.

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Whether you are taking on clinical or basic studies of ocular and organ-specific autoimmunity, your choice of CRO is crucial in regard to the outcome of your study. Put your mind at ease: work with PharmaLegacy.

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Uveitis / Conjunctivitis


Case: Compounds on Bovine IRBP R16-Induced EAU in Lewis Rats

Experimental Procedures

·         Animal species and strain: Lewis rats

·         History of treatment: naive

·         Food: free access to food

·         Water: free access to water

·         Reagents: IRBP R16 solution/ Modified Complete Freund’s Adjuvant (CFA)

Experimental Results

Effect of FTY-720 on Bovine IRBP R16-Induced EAU in Lewis Rats

Histopathology Photo

Case: Compounds on Experiment Allergic Conjunctivitis

Experimental Procedures

· Animal species and strain: BALB/c mice

· History of treatment: Naïve

· Sex, age and weight: Female, 6 – 8 weeks.

· Food: Free access to food

· Water: Free access to water

· Reagent: Ovalbumin (OVA)/ Injection of alum hydroxide solution


Total Score of Hyperemia and Edema

Count of Eye Scratching

Histopathological Eosinophils Detection

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