Preclinical Immunology CRO

The success of your pipeline hinges on restoring the delicate balance between immune stimulation and immune suppression. While the aims may be stated in simple terms, the journey to achieve them is as intricate as the functioning of the immune system itself. To navigate this complex path and reach your goals, you require an experienced guide.

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PharmaLegacy possesses expertise in numerous immune and autoimmune disorders and the models to faithfully reproduce them, making us the perfect partner for conducting complex studies, exploring novel mechanisms of action, and implementing unique therapeutic approaches. With our vast selection of hundreds of models, including numerous non-human primate (NHP) models, we can initiate many studies in as little as two weeks. This ready availability enables us to accelerate research and provide timely insights for our clients.

The quality of your data is intrinsically linked to the reliability of your models and the expertise of the individuals conducting your studies. At PharmaLegacy, we have dedicated decades to developing and refining our models, subjecting each one to rigorous validation. Our team of scientists boasts an average of 15 years of professional scientific experience, with an average of 5 years specifically with PharmaLegacy.

The trust placed in PharmaLegacy by 12 of the top 20 pharmaceutical companies is not coincidental. It is a testament to our commitment to excellence and the unmatched expertise we bring to the field of immunology research. When you choose PharmaLegacy as your immunology contract research organization (CRO), you can expect nothing less than exceptional results and valuable insights that will drive your research forward.

Humanized Mouse Models Humanized Mouse Models

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Our Immune, Autoimmune & Inflammation Models Include:

  1. Cytokines Release PK/PD Models:
    • LPS (Lipopolysaccharide)-induced cytokines release PK/PD model
    • rmTNF-α (recombinant mouse TNF-α) / rhTNF-α (recombinant human TNF-α)-induced cytokines release PK/PD model
    • LPS-ATP-induced cytokines release PK/PD model
    • Zymosan-induced cytokines release PK/PD model
  2. Ear Swelling Models:
    • Xylene-induced ear swelling model
    • Phorbol Ester-induced ear swelling model
  3. Fever Models:
    • LPS-induced fever model
    • Yeast-induced fever model
    • 2,4-Dinitrophenol-induced fever model
  4. Granuloma Models:
    • Agar-induced granuloma model
    • Penicillin-induced granuloma model
  5. Pain Models:
    • Capsaicin / Carrageenan / Complete Freund’s Adjuvant-induced Inflammatory pain models
    • Zymosan-induced Neuropathic pain model
    • Carrageenan / Complete Freund’s Adjuvant-induced Arthritic pain models
    • Incision-induced Postoperative pain model
    • Cancer pain model
  6. Plantar Swelling Models:
    • Carrageenan / Zymosan-induced plantar swelling models
  7. Synovitis Models:
    • LPS-induced synovitis model
    • MSU-induced synovitis model
    • Carrageenan-induced synovitis model
  1. Adjuvant-induced Arthritis (AIA) Model:
    • Adjuvant-induced arthritis in rodents
  2. Collagen Antibody-induced Arthritis (CAIA) Model:
    • Collagen antibody-induced arthritis in rodents
  3. Collagen II-induced Arthritis (CIA) Models:
    • Collagen II-induced arthritis in rodents
    • Collagen II-induced arthritis in non-human primates (NHP)
  4. MSU-induced Gouty Arthritis Model
    • MSU-induced gouty arthritis in rodents
More Info on Arthritis Models
  1. Alopecia Areata Model:
    • Skin graft-induced alopecia areata model
  2. Atopic Dermatitis Models:
    • OXA (Oxazolone)-induced atopic dermatitis model
    • FITC (Fluorescein isothiocyanate)-induced atopic dermatitis model
    • OVA (Ovalbumin)-induced atopic dermatitis model
    • MC903-induced atopic dermatitis model
  3. Contact Dermatitis Models:
    • DNFB (2,4-Dinitrofluorobenzene)-induced contact dermatitis model
    • OXA (Oxazolone)-induced contact dermatitis model
  4. Pruritus Models:
    • Histamine-induced itching model
    • Chloroquine-induced itching model
    • 5-Hydroxytryptamine-induced itching model
  5. Urticaria Model:
    • Anti-DNP IgE-induced urticaria model
  6. Vitiligo Models:
    • Monobenzone-induced vitiligo model
    • Phenylhydroquinone-induced vitiligo model
    • Irradiation-induced vitiligo model
  1. Allergic Conjunctivitis Models:
    • OVA (Ovalbumin)-induced allergic conjunctivitis model
  2. Experimental Autoimmune Uveitis Models:
    • IRBP (Interphotoreceptor Retinoid-binding Protein)-derived peptide R16-induced experimental autoimmune uveitis (EAU) model
More Info on Eye Inflammation Models
  1. Ulcerative Colitis Models:
    • DSS (Dextran Sodium Sulfate)-induced acute colitis in rodents
    • DSS (Dextran Sodium Sulfate)-induced chronic colitis in rodents
    • OXA (Oxazolone)-induced colitis in rodents
  2. Crohn’s Disease Models:
    • TNBS (Trinitrobenzene Sulfonic Acid)-induced colitis in rodents
    • DNBS (Dinitrobenzene Sulfonic Acid)-induced colitis in rodents
  3. Other Colitis Models:
    • CD4+CD45RBhigh T cells-induced colitis in rodents
    • Anti-CD40 antibody-induced colitis in rodents
More Info on Colitis Models
  1. Gout Model
    • Uric Acid Crystals-induced gout in rodents
  2. Hyperuricemia Model
    • Potassium Oxonate-induced hyperuricemia in rodents
  1. Anemia Model in Rheumatoid Arthritis Model:
    • Adjunct-induced anemia model in rheumatoid arthritis
  2. Autoimmune Hemolytic Anemia Model:
    • RBCs (Red Blood Cells)-induced autoimmune hemolytic anemia
  3. Eosinophilia Model:
    • DK-PGD2-induced eosinophilia
  4. Leukopenia Model:
    • Cyclophosphamide-induced leukopenia
  1. Hepatic Fibrosis / Cirrhosis Models
    • CCL4 (Carbon tetrachloride)-induced hepatic fibrosis / cirrhosis models
    • TAA (Thioacetamide)-induced hepatic fibrosis / cirrhosis models
    • Bile Duct Ligation-induced hepatic fibrosis / cirrhosis models
  2. Hepatic Injury Models:
    • Acetaminophen-induced hepatic injury model
    • Concanavalin A-induced hepatic injury model
    • CCL4-induced hepatic injury model
  3. NASH Models:
    • Diet-induced NASH model
    • STZ-Diet-induced NASH model
    • CCL4-Diet-induced NASH model
  1. Type Ⅲ Hypersensitivity Reaction Models:
    • Immune Complex-induced Arthus reaction
  1. IgA Nephropathy (IgAN) Models:
    • BSA-Adjunct-induced IgAN model
    • BSA-LPS-CCL4-induced IgAN model
  2. Kidney Injury Models:
    • Chemotherapy Drugs-induced kidney injury model
    • Surgery-induced kidney injury model
    • Uric Acid-induced kidney injury model
    • Contrast Media-induced kidney injury model
  3. Membranous Nephropathy (MN) Models:
    • Cationic BSA-induced MN model
    • Anti-Fx1A antibody-induced MN model
  4. Nephritis Models:
    • Puromycin aminonucleoside-induced nephritis model
    • Ureteral ligation-induced nephritis model
  5. Renal Fibrosis Model:
    • 5/6 Nephrectomy-induced renal fibrosis model
  1. Systemic Lupus Erythematosus (SLE) Models:
    • Spontaneous models of lupus: MRL/lpr and NZB/W F1 mice
    • Pristane-induced lupus in rodents
    • Trex1-KO mice
  2. Cutaneous Lupus Model:
    • MRL/lpr mice
  3. Lupus Nephritis Models:
    • MRL/lpr and NZB/W F1 mice
  4. Neuropsychiatric Lupus (NPSLE) Models:
    • MRL/lpr and NZB/W F1 mice
More Info on Lupus Models
  1. Demyelination Model:
    • Cuprizone-induced demyelination model
  2. Experimental Autoimmune Encephalomyelitis (EAE) Models:
    • MOG (myelin oligodendrocyte)1-125-induced EAE model
    • MOG (myelin oligodendrocyte)35-55-induced EAE model
    • PLP (proteolipid protein)139-151-induced EAE model
    • MBP (myelin basic protein)-induced EAE model
  3. Experimental Autoimmune Neuritis Model:
    • SP26 (myelin P2 protein)-induced experimental autoimmune neuritis (EAN) model
More Info on Neuroinflammation Models
  1. L-arginine-induced experimental pancreatitis in rodents
  1. IL-23 / IL-23 / IL-33-induced psoriasis-like models
  2. Imiquimod-induced psoriasis-like model
  1. Asthma Models:
    • OVA-induced asthma model
    • HDM-induced asthma model
  2. Bronchospasm Model:
    • Bombesin-induced bronchospasm model
  3. Cough Models:
    • Citric Acid-induced cough model
    • Capsaicin-induced cough model
  4. Chronic Obstructive Pulmonary Disease (COPD) Model:
    • Cigarette smoke-induced COPD
  5. Eosinophilic Pneumonia Model:
    • OVA-induced eosinophilic pneumonia model
  6. Idiopathic Pulmonary Fibrosis (IPF) Models:
    • Bleomycin-induced IPF model
    • Silicon Dioxide-induced IPF model
  7. Silicosis Model:
    • Silicon Dioxide-induced silicosis model
  8. Pneumonia Models:
    • LPA-induced pneumonia model
    • LPS-induced pneumonia model
    • Poly IC-induced pneumonia model
    • Papain-induced pneumonia model
    • Immune Complexes-induced pneumonia model
  9. Rhinitis Model:
    • OVA-induced rhinitis model
  10. Sinusitis Model:
    • OVA-induced sinusitis model
  1. Cecal Ligation and Puncture (CLP)-induced sepsis model
  2. Fecal Extracts-induced sepsis model
  3. LPS-D-galactosamine-induced sepsis model
  4. LPS-induced sepsis model
More Info on Sepsis Models
  1. Graft Versus Host Disease (GVHD) Models:
    • Bone Marrow Transplantation-induced acute GvHD (aGvHD) in rodents
    • Bone Marrow Transplantation-induced chronic GvHD (cGvHD) in rodents
  2. Experimental Autoimmune Myasthenia Gravis (EAMG) Model:
    • AchR (acetylcholine receptor isolated from the electric organ of electric fish) EAMG in rodents
  3. Experimental Autoimmune Myocarditis (EAM) Model:
    • MyHCα334–352 (Cardiac Myosin Heavy Chain)-induced EAM in rodents
    • Capsaicin-induced cough model
  4. Sjögren’s Syndrome Model:
    • Salivary Gland-induced Sjögren’s Syndrome in rodents
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Let PharmaLegacy provide the answers you need.

    Comprehensive Pharmacology Capabilities for Demanding Immunology Studies

    When it comes to immunology studies, no preclinical study can guarantee the exact performance of a therapy in human subjects. However, at PharmaLegacy, we possess extensive experience and expertise in immunology research, providing access to over 1500 validated models, including non-human primate models. These models offer the closest possible predictions for your study’s outcomes. Our commitment to ensuring physiological relevance in our models aims to minimize clinical attrition rates, leading to more successful translational outcomes.

    We understand the significance of reliable research in advancing medical treatments, and that’s why we go beyond standard models. If your study requires a custom model, our team is here to assist you. We continuously develop new models and can tailor them to align with your specific research needs. Rest assured that our model development process is both cost-effective and time-efficient, ensuring your study progresses smoothly without unnecessary delays.

    Choose PharmaLegacy as your preclinical immunology CRO, and let our comprehensive pharmacology capabilities support your demanding research requirements. Reach out to us today and discover how our expertise can elevate your research to new heights.

    START YOUR IMMUNOLOGY STUDY TODAY

      Why wait months to start your immunology study? We maintain ready availability of all of our advertised models and can generally begin a study in under two weeks!

      With our massive catalog of over 1500 readily available models, our scientific staff averaging over 15 years of experience, and our surprisingly affordable pricing, we have been the go-to preclinical pharmacology provider for many global pharmaceutical giants. See what over 300 global pharmaceutical and biotech companies, including 12 of the top 20 pharma companies, have realized: when you choose PharmaLegacy, you can expect more.

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      Can you trust your animal model to provide you with the correct answers?

      No animal study can predict with complete certainty how a therapy will perform in human subjects, but it is PharmaLegacy’s job to ensure that you come as close to certainty as possible. Download our brochure on non-human primate (NHP) models of immune, autoimmune, and inflammatory disorders and see how PharmaLegacy ensures that your studies utilize the most physiologically relevant models.

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      Download the Case Study