NHP Models / NHP Studies

With a wide breadth of available NHP models, a substantial non-human primate capacity, deep experience, and immediate availability for many models, PharmaLegacy is uniquely suited to run your NHP studies.

Availability + Experience

Finding a partner with the non-human primate models you need, and one who can start your study quickly, can seemingly be a tall order. That is the key problem which PharmaLegacy solves. We maintain ready availability of the vast majority of our NHP models, and other animal models, so we can begin your study in as little as two weeks. As the saying goes: time is money. You’ll be able to make the most of both with PharmaLegacy.

PharmaLegacy puts a wide range of NHP models at your service. Our available models span immunity and inflammation, metabolism, ophthalmology, hematology and thrombosis, pain, wound healing, cardiology, and more. We can further leverage NHPs in your pharmacokinetics, pharmacodynamics, and toxicology studies, providing you with the most clinically relevant insights you can get outside of a clinical setting.

With our scientific staff averaging over 15 years of experience, there is no cutting corners. You can simply expect more when you work with PharmaLegacy.

OUR NON-HUMAN PRIMATE MODELS & SERVICES INCLUDE:

  • Arteriovenous Bypass (AV-shunt) Thrombosis Model
  • Balloon Injury-Induced Arterial Thrombosis
  • Bleeding Time Test in Rat Tail or Rabbit Ear / Nail or Arm-skin of Cynos
  • Collagen / FⅧ Induced Hemophilia
  • FeCl3 Induced Thrombosis Model
  • Heart Failure Model
  • Hemorrhagic Stroke Model
  • Immune Thrombocytopenia (ITP) Model Induced by an Anti-GPIIb/IIIa Antibody
  • IVC Stenosis Model of Venous Thrombosis
  • Middle Cerebral Artery Occlusion (MCAO) Induced Stroke Model
  • Myocardial Infarction
  • Myocardial Ischemia / Reperfusion Injury in Rat
  • Venous Bypass Thrombosis Model (V-shunt)
More Info on Hematology & Thrombosis NHP Models
  • Blood Cell Culture Stimulation Experiment In Vitro
  • Coagulation Measurement
  • In Vitro Determination of Dose-effect of Anticoagulants
  • In Vitro Measurement of Platelet Aggregation
More Info on In Vitro NHP Services
  • Acute Hepatitis Induced by Acetaminophen
  • Asthma-like Th2 Response Induced by Multiple A.Suum Challenges in Monkey
  • B-cell Depletion Therapy
  • Balloon Synovitis of the Back
  • Bile Duct Ligation Induced Hepatic Fibrosis
  • Bleomycin-induced Pulmonary Fibrosis
  • Chemotherapy Induced Mucositis Model
  • Collagen II-induced Rheumatoid Arthritis (RA) Model
  • Dextran Sulfate Sodium (DSS)-induced Colitis Model
  • Endometriosis Model Induced by Ectopic Implantation
  • Escherichia Coli Induced Skin Blister
  • I.V Low Dose of Lipopolysaccharide (LPS)-induced Cytokines Production Model
  • Induced Atopic Dermatitis
  • Wheal and Flare Skin Testing
  • Inflammatory Anemia Model
  • Intrabronchial LPS-induced Acute Lung Injury (ALI) Model
  • Keyhole Limpet Hemocyanin (KLH)-induced T cell Dependent Antibody Response (TDAR) Model
  • LPS-induced Systemic Inflammation Model
  • MOG Induced EAE
  • Tetanus Toxoid (TTx)-induced Delayed Type Hypersensitivity (DTH) Model
  • Stem cell isolation and transplant
  • GVHD
More Info on NHP Inflammation & Immune Models
  • Animal Model of Hyperuricemia
  • Gastric Peristalsis Model
  • Functional Dyspepsia
  • Hyperlipidemia Model
  • Intravenous Glucose Tolerance Test (IVGTT) / Oral Glucose Tolerance Test (OGTT) Model
More Info on Metabolic NHP Models
  • Antibody Drug Conjugate (ADC) Induced Corneal Toxicity
  • Efficiency and Efficacy Evaluation of Ocular Gene Therapy
  • Laser-induced Choroidal Neovascularization (CNV) Model
More Info on NHP Ophthalmology Models
  • Anti-Drug Antibody Test (ADA)
  • Non-GLP Toxicology Experiment
  • Pharmacokinetic Analysis Test
  • PK-APTT Steady-state Dose Exploration Test
  • CAR-T production and PK
  • Cell depletion and antibodies studies
  • Novel biologic PK and PK/PD
  • LNP: RNA/ RNAi distribution
  • Blood Cell Apheresis
  • Cutaneous Wound Healing and Scarring
  • Plantar Pain Caused by Dorsal Root Nerve Ligation
More Info on Other NHP Models
START YOUR NHP STUDY NOW

Facilities & Sourcing for Non-Human Primates

Our research laboratories at PharmaLegacy are equipped to house more than 350 NHPs for your studies, with capacity for another 30,000 Cynomolgus and Rhesus monkeys available off-site.

We are acutely cognizant of the concern for the ethical sourcing and treatment of animals. PharmaLegacy has repeatedly audited its non-human primate supply chain and affirmed that all of its NHPs are farm-raised for research use. Supplier providence and detailed animal information can be provided to all clients upon request.

PharmaLegacy is an AAALAC accredited facility.

START YOUR NON-HUMAN PRIMATE STUDY TODAY

    NHPs account for less than half a percent of all animals used in medical research, but they have a disproportionate impact on the knowledge that is gained from preclinical studies. NHP models are a critical means to accelerate our understanding of investigational therapies and, in turn, accelerate your pipelines. Contact PharmaLegacy today and let’s get the answers you need.

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    PharmaLegacy & NHP: Succeeding Where Other Models Fail

    There is a wide difference in clinical relevance between rodents and non-human primates when it comes to collagen-induced arthritis models. PharmaLegacy’s CIA models of human rheumatoid arthritis utilizing cynomolgus monkeys are optimized for similarities in clinical presentation, biomarkers, and practical considerations which improve study efficiency. See how in our NHP Arthritis case study.